Senior Bioanalytical Chemist

About the Position

Mobius Biomedical is a rapidly growing, early-stage biotech company that is focused on developing innovative, pathbreaking bioprocess equipment and technologies to dramatically reduce the costs of traditional biologics manufacturing.

Mobius Biomedical is searching for a qualified, highly motivated bioanalytical chemist to join our team on the ground floor as a Senior Bioanalytical Chemist to perform characterization of biopharmaceutical products. This position reports directly to the Chief Scientific Officer.

Primary Responsibilities

  • Characterization of biopharmaceutical products, including proteins and other biologic macromolecules, using spectrophotometric, chromatographic, and other analytical and bioanalytical instrumentation.
  • Develop UV-Vis spectrometry, microplate reader, BCA assay, Bradford assay, ELISA, gel electrophoresis, SDS-PAGE, Western Blot, Isoelectric focusing, ITC, SPR, HPLC/UPLC, SEC, affinity chromatography, ion-exchange chromatography (IEX), hydrophobic interaction chromatography (HIC), circular dichroism, and other bioanalytical assays and methods.
  • Work with interdisciplinary R&D teams to design and perform appropriate analytical experiments to advance process technology development.
  • Work with the engineering and process development teams to develop methods for “in-process” and “in-line” testing.
  • Select, install, and implement analytical instrumentation.
  • Maintain and troubleshoot analytical instruments.
  • Design and execute method development, qualification and validation.
  • Communicate results and observations to the analytical, engineering, and process development teams through strong written and oral communication skills.
  • Maintain GLP compliant lab records, lab notebooks, and procedures.
  • Maintain a safety-first approach to science.
  • Think creatively, problem solve, and develop innovative solutions based on sound scientific analysis.
  • Other duties as required

Qualifications
PhD in Chemistry, Analytical Chemistry, or Bioanalytical Chemistry with 2-5 years of hands-on experience with analytical measurements and instrumental analysis in the biopharmaceutical or biotechnology industry,

or

MS in Chemistry, Analytical Chemistry, or Bioanalytical Chemistry with 5-8 years of hands-on experience with analytical measurements and instrumental analysis in the biopharmaceutical or biotechnology industry.

Preferred Skills

  • Experience with biopharmaceutical products, including the purification and characterization of proteins, monoclonal antibodies, oligonucleotides, and viral vectors.
  • Experience with selecting and installing new analytical instrumentation.

Required Skills

  • Strong experience with biomolecule quantification, including, UV-Vis spectrometry, micro-plate reader-based assays, BCA assay, Bradford assay, ELISA, gel electrophoresis, SDS-PAGE, Western Blot, Isoelectric focusing, SPR, ITC, zeta potential, dynamic light scattering, and circular dichroism.
  • Experience with biomolecule separation, including, SEC, affinity chromatography, ion-exchange chromatography (IEX), and hydrophobic interaction chromatography (HIC).
  • Experience with analytical and bioanalytical methods development, qualification, and validation.
  • Experience with writing SOPs.
  • Experience working in a GLP/cGMP environment.
  • Ability to design and execute controlled experiments with a strong attention to detail is essential.
  • Driven self-starter with capability to work independently as well as on interdisciplinary teams with chemists, biochemist, biophysicists, biomedical engineers, chemical engineers, mechanical engineers, electrical engineers, controls engineers, analytical chemists, materials scientists, biologists, etc.
  • Comfortable working on high-risk technologies in a fast paced, dynamic start-up environment.
  • Proficient computer skills including MS Office and statistical analysis software.
  • Proficient oral and written communication skills.

Compensation
Mobius Biomedical offers a highly competitive salary commensurate with experience, Incentive Stock Options (ISOs), medical, dental, and vision benefits, short- and long-term disability, flexible spending account (FSA), and life insurance.

Position Type: Full-time

Position Location: Lowell, MA

Authorization to work in the U.S. is required.

 

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